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NYHNI Researchers Publish New Diagnosis Techniques in Thyroid Cancer

8/7/2018
Researchers led by Dr Daniel Kuriloff at the NYHNI have published a new diagnostic technique for thyroid cancer, specifically Hurthle Cell Cancer.
Researchers led by Dr Daniel Kuriloff at the NYHNI have published a new diagnostic technique for thyroid cancer, specifically Hurthle Cell Cancer.

Thyroseq V3 Molecular Profiling for Tailoring the Surgical Management of Hürthle Cell Neoplasms
Authors: Sarah Pearlstein, Arash H. Lahouti, ElanaOpher, Yuri E. Nikiforov, and Daniel B.Kuriloff
 
Hürthle cell predominant thyroid nodules often confound the diagnostic utility of fine needle aspiration biopsy (FNAB) with cytology often interpreted as a Hürthle cell lesion with an indeterminate risk of malignancy, Bethesda category (BC) III or IV. Molecular diagnostics for Hürthle cell predominant nodules has also been disappointing in further defining the risk of malignancy. We present a case of a slowly enlarging nodule within a goiter initially reported as benign on FNAB, BC II but on subsequent FNAB suspicious for a Hürthle cell neoplasm, BC IV. The patient had initially requested a diagnostic lobectomy for a definitive diagnosis despite a higher risk of malignancy based on the size of the nodule > 4 cm alone. To better tailor this patient’s treatment plan, a newer expanded gene mutation panel, ThyroSeq® v3 that includes copy number alterations (CNAs) and was recently found to have greater positive predictive value (PPV) for identifying Hürthle cell carcinoma (HCC), was performed on the FNAB material. Molecular profiling with ThyroSeq® v3 was able to predict a greater risk of carcinoma, making a more convincing argument in favor of total thyroidectomy. Surgical pathology confirmed a Hürthle cell carcinoma with 5 foci of angioinvasion and foci of capsular invasion. 

Correspondence should be addressed to Daniel B.Kuriloff; dkuriloff@northwell.edu

Case Reports in Endocrinology

Volume 2018, Article ID 9329035, 4 pages
 
https://www.hindawi.com/journals/crie/2018/9329035/
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